Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea.
Identifieur interne : 001596 ( Main/Exploration ); précédent : 001595; suivant : 001597Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea.
Auteurs : Catherine Bédard [Canada] ; Marie-Josée Wallman ; Emmanuelle Pourcher ; Peter V. Gould ; André Parent ; Martin ParentSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Corpus Striatum (enzymology), Corpus Striatum (metabolism), Corpus Striatum (pathology), Dopamine (physiology), Dopaminergic Neurons (enzymology), Dopaminergic Neurons (metabolism), Dopaminergic Neurons (pathology), Female, Humans, Huntington Disease (enzymology), Huntington Disease (metabolism), Huntington Disease (pathology), Male, Middle Aged, Parkinson Disease (enzymology), Parkinson Disease (metabolism), Parkinson Disease (pathology), Presynaptic Terminals (enzymology), Presynaptic Terminals (metabolism), Presynaptic Terminals (pathology), Serotonin Plasma Membrane Transport Proteins (physiology), Tyrosine 3-Monooxygenase (physiology).
- MESH :
- chemical , physiology : Dopamine, Serotonin Plasma Membrane Transport Proteins, Tyrosine 3-Monooxygenase.
- enzymology : Corpus Striatum, Dopaminergic Neurons, Huntington Disease, Parkinson Disease, Presynaptic Terminals.
- metabolism : Corpus Striatum, Dopaminergic Neurons, Huntington Disease, Parkinson Disease, Presynaptic Terminals.
- pathology : Corpus Striatum, Dopaminergic Neurons, Huntington Disease, Parkinson Disease, Presynaptic Terminals.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
In contrast to our vast knowledge of the dopamine (DA) system, much less is known about the involvement of serotonin (5-HT) in neurodegenerative diseases affecting the basal ganglia. Therefore, we designed a study that aimed at characterizing the status of the striatal DA and 5-HT systems in patients who suffered from either Parkinson's (PD) or Huntington's disease (HD), compared to age-matched controls. Antibodies against tyrosine hydroxylase (TH) and 5-HT transporter (SERT) were used as markers of DA and 5-HT axonal profiles, respectively. The density and pattern of TH+ and SERT + innervation were determined by optical density measurements as well as by direct stereological estimates of labeled axon varicosities. The results reveal a significant decrease in TH immunoreactivity and TH + axon terminals throughout the striatum in both PD and HD, whereas the intensity of SERT immunostaining and the density of SERT + axon varicosities were found to be slightly increased in the striatum of PD and HD patients compared to controls. These findings reveal that the nigrostriatal DA system is significantly impaired in both PD and HD compared to the striatal 5-HT innervation, which is slightly increased in these two conditions. The striatal 5-HT augmentation observed in PD might be the result of a neural mechanism designed to compensate for DA denervation, whereas the marked atrophy of the striatum might explain the increase in the 5-HT innervation noted in HD. These findings underline the importance of the complex interplay between DA and 5-HT striatal afferents in the elaboration of appropriate motor behaviour.
DOI: 10.1016/j.parkreldis.2011.05.012
PubMed: 21664855
Affiliations:
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Gould</name></author><author><name sortKey="Parent, Andre" sort="Parent, Andre" uniqKey="Parent A" first="André" last="Parent">André Parent</name></author><author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21664855</idno><idno type="pmid">21664855</idno><idno type="doi">10.1016/j.parkreldis.2011.05.012</idno><idno type="wicri:Area/PubMed/Corpus">000B84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B84</idno><idno type="wicri:Area/PubMed/Curation">000B84</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B84</idno><idno type="wicri:Area/PubMed/Checkpoint">000B84</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B84</idno><idno type="wicri:Area/Ncbi/Merge">000E94</idno><idno type="wicri:Area/Ncbi/Curation">000E94</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E94</idno><idno type="wicri:Area/Main/Merge">001661</idno><idno type="wicri:Area/Main/Curation">001596</idno><idno type="wicri:Area/Main/Exploration">001596</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea.</title><author><name sortKey="Bedard, Catherine" sort="Bedard, Catherine" uniqKey="Bedard C" first="Catherine" last="Bédard">Catherine Bédard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, & Centre de Recherche Université Laval Robert-Giffard, Quebec City, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, & Centre de Recherche Université Laval Robert-Giffard, Quebec City, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Wallman, Marie Josee" sort="Wallman, Marie Josee" uniqKey="Wallman M" first="Marie-Josée" last="Wallman">Marie-Josée Wallman</name></author><author><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name></author><author><name sortKey="Gould, Peter V" sort="Gould, Peter V" uniqKey="Gould P" first="Peter V" last="Gould">Peter V. Gould</name></author><author><name sortKey="Parent, Andre" sort="Parent, Andre" uniqKey="Parent A" first="André" last="Parent">André Parent</name></author><author><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Corpus Striatum (enzymology)</term><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Dopamine (physiology)</term><term>Dopaminergic Neurons (enzymology)</term><term>Dopaminergic Neurons (metabolism)</term><term>Dopaminergic Neurons (pathology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (enzymology)</term><term>Huntington Disease (metabolism)</term><term>Huntington Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (enzymology)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Presynaptic Terminals (enzymology)</term><term>Presynaptic Terminals (metabolism)</term><term>Presynaptic Terminals (pathology)</term><term>Serotonin Plasma Membrane Transport Proteins (physiology)</term><term>Tyrosine 3-Monooxygenase (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term><term>Serotonin Plasma Membrane Transport Proteins</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Huntington Disease</term><term>Parkinson Disease</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Huntington Disease</term><term>Parkinson Disease</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Dopaminergic Neurons</term><term>Huntington Disease</term><term>Parkinson Disease</term><term>Presynaptic Terminals</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to our vast knowledge of the dopamine (DA) system, much less is known about the involvement of serotonin (5-HT) in neurodegenerative diseases affecting the basal ganglia. Therefore, we designed a study that aimed at characterizing the status of the striatal DA and 5-HT systems in patients who suffered from either Parkinson's (PD) or Huntington's disease (HD), compared to age-matched controls. Antibodies against tyrosine hydroxylase (TH) and 5-HT transporter (SERT) were used as markers of DA and 5-HT axonal profiles, respectively. The density and pattern of TH+ and SERT + innervation were determined by optical density measurements as well as by direct stereological estimates of labeled axon varicosities. The results reveal a significant decrease in TH immunoreactivity and TH + axon terminals throughout the striatum in both PD and HD, whereas the intensity of SERT immunostaining and the density of SERT + axon varicosities were found to be slightly increased in the striatum of PD and HD patients compared to controls. These findings reveal that the nigrostriatal DA system is significantly impaired in both PD and HD compared to the striatal 5-HT innervation, which is slightly increased in these two conditions. The striatal 5-HT augmentation observed in PD might be the result of a neural mechanism designed to compensate for DA denervation, whereas the marked atrophy of the striatum might explain the increase in the 5-HT innervation noted in HD. These findings underline the importance of the complex interplay between DA and 5-HT striatal afferents in the elaboration of appropriate motor behaviour.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Gould, Peter V" sort="Gould, Peter V" uniqKey="Gould P" first="Peter V" last="Gould">Peter V. Gould</name><name sortKey="Parent, Andre" sort="Parent, Andre" uniqKey="Parent A" first="André" last="Parent">André Parent</name><name sortKey="Parent, Martin" sort="Parent, Martin" uniqKey="Parent M" first="Martin" last="Parent">Martin Parent</name><name sortKey="Pourcher, Emmanuelle" sort="Pourcher, Emmanuelle" uniqKey="Pourcher E" first="Emmanuelle" last="Pourcher">Emmanuelle Pourcher</name><name sortKey="Wallman, Marie Josee" sort="Wallman, Marie Josee" uniqKey="Wallman M" first="Marie-Josée" last="Wallman">Marie-Josée Wallman</name></noCountry><country name="Canada"><noRegion><name sortKey="Bedard, Catherine" sort="Bedard, Catherine" uniqKey="Bedard C" first="Catherine" last="Bédard">Catherine Bédard</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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